Amgen Scholars Program

Links and Functions

Breadcrumb Navigation


Faculty Members

Surname, First name Research Focus Availability
Baier, Herwig The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses. not available
Becker, Peter B. We are interested in how functional states derive from the interplay of opposing principles: those that endow chromatin structures with plasticity and enable a cell to respond to developmental, metabolic and environmental signals, and others, promoting the assembly of lasting, heritable structures that organise chromosomes and define cellular identity. not available
Benakis, Corinne Stroke is one of the leading causes of death and mortality worldwide. One of the main risk factors for stroke onset is exposure to environmental toxins. Some of these environmental toxins that affect human health include dioxins and polyaromatic hydrocarbons. Both compounds have a high affinity for the aryl hydrocarbon receptor (AhR) which is ubiquitously expressed in immune cells at barrier sites, including the gut, the lung and meninges. For this project, we will test specific environmental toxins, ligands of AhR, and characterize the immune response and microbial composition before and after exposure to the toxin and evaluate the impact on stroke severity in mice. available
Bonhoeffer, Tobias We investigate the fundamental principles of synaptic plasticity at a number of different levels, ranging from molecular approaches to studies of the intact nervous system. not available
Brandt, Thomas In the Institute of Clinical Neurosciences, studies address vestibular function in health and disease from eye movement recordings to perception using various methods such as psychophysical measurements, eye movement recordings, fMRI and computational modeling. not available
Cordes, Thorben Monitoring membrane transport processes with fluroescent chemosensors. available
Ertürk, Ali Project 1: Advanced Imaging of Cancer Metastasis in Whole Mouse Body / Project 2: Whole-body imaging of nanoparticles available
Franzmeier, Nicolai Our overarching goal is to better understand the mechanisms that promote the development and progression of Alzheimer’s disease in order to develop clinically applicable personalized medicine models for predicting patient-specific disease trajectories. not available
Gires, Olivier Based on the findings on EMT in HNSCC, the aims of the project are two-fold. Firstly, we aim to further explore the novel regulatory networks of EGFR in HNSCC and identify gene signature(s) characterizing EGFR-mediated EMT from preclinical to clinical status to improve HNSCC stratification with a special focus on local recurrences, lymph node status, and response to EGFR-specific therapeutic agents. Secondly, we aim to identify prospective therapeutic targets, i.e. genes that make up EGFR-mediated signatures will be further described at the functional, molecular level in adequate cellular models. available
Gogolla, Nadine Our lab is interested in understanding neuronal circuit functions of the insular cortex as part of a wider neuronal network comprising prefrontal and limbic brain structures. not available
Grothe, Benedikt We are interested in the neuronal mechanisms of temporal auditory processing and their evolution in mammals. In particular, our studies are concerned with the role of neural inhibition in temporal processing. not available
Hartl, Ulrich Research in Hartl and Hayer-Hartl laboratory focuses on the mechanisms of protein folding and quality control in the cell. Our goal is to reach a comprehensive understanding, at the structural and functional level, of how the machinery of molecular chaperones assists folding through the co­operation of co- and post-translational mechanisms. available
Hayer-Hartl, Manajit The discovery and functional analysis of the chaperonins was instrumental in shaping our present view of de novo protein folding as a chaperone-assisted process. not available
Hemmert, Werner We focus our research on the auditory system where we combine modelling studies with experiments to develop novel approaches for the advancement of neuroprosthetics. not available
Herms, Jochen Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD. not available
Herz, Andreas Data analysis, computational/mathematical modelling and theoretical investigation of neurobiological mechanisms underlying spatial orientation and navigation. Focus: Single-cell and network behavior of head-direction and grid-cell systems within the rodent entorhinal cortex. available
Imhof, Axel We study the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus. available
Jung, Kirsten The Jung lab has a long-standing interest in stress response and transmembrane signal transduction in the enterobacterium Escherichia coli, the marine bacterium Vibrio harveyi and the entomopathogen Photorhabdus luminescens. available
Keays, David The Keays laboratory is interested in the molecules, cells and circuits that allow animals to detect magnetic fields. This project will explore the molecular architecture of a neuronal circuit that encodes magnetic information within the pigeon brain. available
Kielkowski, Pavel Determination of mass spectrometric properties of tubulin modified C-terminal peptides available
Klein, Rüdiger The amygdala is a cluster of highly conserved nuclei at the base of the brain, important for appetitive and aversive behaviours. We use viral tracing, behaviour, histology and electrophysiology to answer the questions related. available
Kopp-Scheinpflug, Conny Our laboratory is interested in how ambient sensory stimulation activates neuromodulators and how these then influence the processing of relevant information. not available
Korber, Philipp We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning. not available
Kunz, Hans-Henning The research in our group is strongly focused on the plant chloroplasts and transport processes in this organelle. We are particularly interested in ion transport proteins. Currently, we are working on the identification of their substrates and molecular mechanisms. In this context we are interested in organelle development, stress signals and photosynthesis. In our studies we mainly use Arabidopsis thalian as a plant model organism. With growing enthusiasm, however, we are also interested in algae. not available
Kunz, Lars Our major research focus is on the correlation of cellular metabolism (energy production and consumption) and electrical activity in neurones. not available
Ladurner, Andreas Next summer, join us in investigating the intricate link between glucose metabolism, transcriptional control and gene regulation in eukaryotes. Our project focuses on how the sugar-tolerance transcription factor ChREBP and its paralogs directly sense cellular metabolites to drive large changes in gene activity. available
Lichtenthaler, Stefan We study how Alzheimer’s disease develops in the brain on the molecular and cellular level. The aim of our research is to better understand the disease causes and to develop new diagnostic, therapeutic and preventive approaches. not available
Michalakis, Stylianos We have previously established a novel primary microglia culture protocol from mouse retina, which allows for good reproducibility, high cell numbers and long in vitro viability. In order to be able to efficiently manipulate retinal microglia in vivo and in vitro, efficient gene delivery technologies are needed. Within this project, we will evaluate novel-engineered adeno-associated virus (AAV) capsids regarding efficacy and specificity. These AAV variants will be tested in our mouse retinal microglia culture model, mouse retinal explant cultures and in a mouse model of retinal degeneration to validate their efficacy and specificity in vitro, ex vivo and in vivo. available
Misgeld, Thomas The Misgeld lab uses in vivo imaging methods (ranging from wide-field time-lapse to two-photon microscopy) to study the development and degeneration of neurons and their processes. not available
Myoga, Michael H. We study how spatial information from multiple senses converges in the midbrain of mice. With a focus on how auditory information integrates with its visual counterparts, we employ in vitro patch-clamp electrophysiology, optogenetic-based circuit mapping, and anatomical tracing techniques. not available
Nägele, Thomas To promote our understanding of how plants acclimate to a changing environment, our research focuses on the quantitative analysis of metabolic regulation. not available
Niessing, Dierk Our goal is to understand the molecular principles underlying cargo recognition by transport complexes, complex assembly and activation, and eventually complex disassembly after the transport. not available
Ninkovic, Jovica We focus on basic and translational research in the field of the central nervous system (CNS) repair and regeneration aiming at novel strategies for brain repair and regeneration by modulating the function of glial cells. We aim at providing a basis for the development of new therapies for patients affected by stroke, neurotrauma or neurodegenerative diseases. not available
Plesnila, Nikolaus The main interest of the laboratory is to study the role of cerebral vessels for the pathophysiology of acute and chronic brain injury and to use the evolving knowledge for the development of novel therapeutic strategies for patients. For this purpose we use clinically relevant mouse models for acute and chronic brain injury and investigate neuro-vascular morphology and function by in vivo microscopy using conventional and 2-photon fluorescence microscopy. not available
Ploner, Markus On a systems neuroscience level we are working on the brain mechanisms of pain perception. We aim to further the understanding of the brain processes, which determine the individual sensitivity of a person to pain, which explain why we perceive the same painful event differently in different situations. not available
Portugues, Ruben My group is interested in how brains process sensory stimuli and use them to select appropriate motor output. not available
Sattler, Michael The Amgen scholar will be involved in designing (cloning) and optimizing (purification) different protein constructs followed by screening LLPS conditions using microscopy and biochemical characterization, ie protein-protein interactions, using nuclear magnetic resonance (NMR) spectroscopy, electron microscopy (EM) and other biophysical techniques (ITC, SLS), which will ultimately provide foundation to obtain a structural model of the peroxisomal protein import machinery. available
Schmidt, Mathias V. Project 1: Characterizing long-term outcomes of developmental stress exposure in a translational mouse model / Project 2: Investigation into the Role of FKBP51 in Obesity and Type 2 Diabetes available
Sirota, Anton Our research is focused on the mechanisms of information representation and propagation within and across different cortical networks. not available
Stricker, Stefan H. The research aim of the lab is to investigate how cells know which cell type they are and why they never forget. We employ a wide range of CRISPR methods to brain cells to test in vitro and in vivo, which epigenetic marks and gene activities have functional relevance in mediating cell identity or disease phenotypes. not available
Tiedt, Steffen We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome. not available
Turck, Christoph W. The comparison of the proteome of diseased and healthy tissues and body fluids and the subsequent identification of the proteins that are different from normal in disease are pursued in order to unravel the pathogenesis of disease, to identify therapeutic targets, and to develop diagnostic tests. not available
Vollmar, Angelika The biochemical pathway of chlorophyll degradation has only recently been characterized. The metabolites that are yielded from the breakdown path – the phyllobilins – were shown to have antioxidant properties. not available
Wachtler, Thomas We perceive visual features such as color, form, or size of objects not in isolation but depending on the visual context. Contextual influences are thought to play an important role in reliable and efficient perception. In this project we will perform quantitative measurements of visual performance and use models of neural processing to investigate the neural mechanisms underlying contextual influences on visual perception. available
Wagner, Ernst Novel molecular therapeutics like siRNA, microRNAs or antagomiRs require potent extracellular and intracellular delivery devices to be effective antitumor agents. not available
Willem, Michael The Laboratory for Neurodegenerative Disease Research focuses on the generation of Amyloid ß-peptide (Aß) as the major constituent of neurotoxic amyloid plaques in Alzheimer's Disease (AD). not available

Please do not contact faculty members directly. Only applications sent through our application tool within the deadline will be considered.