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Prof. Dr. Andreas Ladurner

Chair, Professor of Physiological Chemistry

Affiliation

LMU Medical Faculty, Department of Physiological Chemistry

Contact

Biomedical Center Munich
Department of Physiological Chemistry
Ludwig-Maximilians-Universität
Großhaderner Str. 9
82152 Planegg-Martinsried
Germany

Phone: (089) 2180 77095
Fax: (089) 2180 77093

Website: http://www.physiolchemie.abi.med.uni-muenchen.de/research/ladurner/index.html

Research Focus

Molecular mechanisms of chromatin plasticity

In the eukaryotic nucleus most of our genetic information is packaged into a structure called chromatin. Whenever cells need to change their genetic programme, such as when the environment or growth conditions change, chromatin structure has to be actively remodelled. Our team is interested in identifying, characterizing and then exploiting novel molecular mechanisms that underlie this level of regulatory plasticity in chromatin structure. We are thus uncovering some of the fundamental mechanisms that govern the function of our complex genome and its ability to adapt to new environments. A focus of our group lies in the role of post-translational modifications (in particular, acetylation and ADP-ribosylation signalling networks) and of cellular metabolites in regulating the assembly and remodelling of chromatin, for example through the regulation of ATP-dependent chromatin remodellers.